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Data Analysis Publications

  • Population model stability and performance.
    • Ette EI. Population model stability and performance. J Clin Pharmacol, 1997; 37: 486 - 495.
  • Comparing non-hierarchical models: application to nonlinear mixed effects modeling.
    • Ette EI. Comparing non-hierarchical models: application to nonlinear mixed effects modeling. Computers Biol Med 1996; 26: 505 -512.
  • Population pharmacokinetic modeling: the importance of informative graphics.
    • Ette EI, Ludden TM. Population pharmacokinetic modeling: the importance of informative graphics. Pharm Res 1995; 12 (12): 1845 - 1855.
  • Statistical graphics in pharmacokinetics and pharmacodynamics: a tutorial.
    • Ette EI. Statistical graphics in pharmacokinetics and pharmacodynamics: a tutorial. Ann Pharmacother 1998; 32: 818 - 828.
  • Estimating inestimable standard errors in population Pharmacokinetic studies: the bootstrap with winsorization.
    • Ette EI, Onyiah LC. Estimating inestimable standard errors in population Pharmacokinetic studies: the bootstrap with winsorization. Eur J Drug Metab Pharmacokinet 2002; 27: 213 – 224.
  • The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis.
    • Godfrey C, Sweeney K, Miller K, Hamilton R, Kremer J. The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis. Br J Clin Pharmacol. 1998 Oct;46(4):369-376.
  • Communicating Pharmacometric Analysis Outcome.
    • Ette EI, Onyiah LC. Communicating Pharmacometric Analysis Outcome. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 925 – 934.
  • The Confluence of Pharmacometric Knowledge Discovery and Creation in the Characterization of Drug Safety.
    • Chu H-M, Ette EI. The Confluence of Pharmacometric Knowledge Discovery and Creation in the Characterization of Drug Safety. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007
  • Data supplementation: A pharmacokinetic / pharmacodynamic knowledge creation approach for characterizing an unexplored region of the response surface.
    • Ette EI, Chu H-M, Godfrey CJ. Data supplementation: A pharmacokinetic / pharmacodynamic knowledge creation approach for characterizing an unexplored region of the response surface. Pharm Res 2004; 22: 523 – 531.
  • Model appropriateness and population pharmacokinetic modeling.
    • Ette EI, Williams PJ, Kim YH, Lane JR, Liu M-J, Capparelli. Model appropriateness and population pharmacokinetic modeling. J Clin Pharmacol 2003; 43: 610 – 623.
  • The Process of knowledge discovery from large pharmacokinetic data sets.
    • Ette EI, Williams P, Sun H, et al. The Process of knowledge discovery from large pharmacokinetic data sets. J Clin Pharmacol 2001 (1); 41: 25 – 34.
  • Population pharmacokinetic / pharmacodynamic modeling of ordered categorical longitudinal data.
    • Ette EI, Roy A, Nandy P. Population pharmacokinetic / pharmacodynamic modeling of ordered categorical longitudinal data. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 655 – 688.
  • Mixed effects modeling analysis of count data.
    • Godfrey CJ. Mixed effects modeling analysis of count data. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 699 – 721.
  • Data imputation.
    • Ette EI, Chu H-M, Ahmad A. Data imputation. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 245 – 262.
  • Determination of Model Appropriateness.
    • Williams PJ and Ette EI. Determination of Model Appropriateness. In: Clinical Trial Simulations. Kimko HC, Duffil S (eds). New York: Marcel Dekker, 2002, pp 73 - 104.
  • Comparison of the effects of rifampin and rifabutin on the pharmacokinetics and pharmacologic effects of a combined oral contraceptive.
    • Barditch-Crovo P, Flexner C, Ette EI, Trapnel C. Comparison of the effects of rifampin and rifabutin on the pharmacokinetics and pharmacologic effects of a combined oral contraceptive. Clinical Pharmaol Ther 1999; 66: 428 – 438.
  • Estimating the dynamics of drug regimen compliance.
    • Ette EI, Ahmad A. Estimating the dynamics of drug regimen compliance. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 165 – 181.
  • The epistemology of pharmacometrics.
    • Williams PJ, Kim YH, Ette EI. The epistemology of pharmacometrics. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp223 – 244.
  • A Random Sampling Approach for Robust Estimation of Tissue-to-Plasma Ratio From Extremely Sparse Data.
    • H-M Chu, and EI Ette. A Random Sampling Approach for Robust Estimation of Tissue-to-Plasma Ratio From Extremely Sparse Data.  AAPS J 2005; 7(1) E249-E258.
  • Modeling Toxicological Multivariate Mortality Data: A Bayesian Perspective.
    • Sinha, Dey and Chu. Modeling Toxicological Multivariate Mortality Data: A Bayesian Perspective. In: Springer Lecture Notes in Statistics: Modeling in longitudinal and spatially Correlated Data: Methods, Applications and Future directions. Springer Verlag. 122, 123-134, 1997.
  • Sampling Based Approach for One-Hit and Multi-Hit Models in Quantal Bioassay.
    • Chu and Kuo. Sampling Based Approach for One-Hit and Multi-Hit Models in Quantal Bioassay. Statistics and Computing 1997; 7: 183-192
  • Transition models in pharmacodynamics.
    • Ette EI. Transition models in pharmacodynamics. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 689 – 698.
  • Population Pharmacokinetic Estimation Methods.
    • Ette EI, Williams PJ, Ahmad A. Population Pharmacokinetic Estimation Methods. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, pp 265 -285.
  • Pharmacometric knowledge discovery from clinical trial data sets.
    • Ette EI. Pharmacometric knowledge discovery from clinical trial data sets. In: Pharmacometrics: the Science of Quantitative Pharmacology. Ette EI, Williams PJ (eds). Hoboken: John Wiley & Sons, 2007, 383 – 399.
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